ARC is conducting a vaccine study aimed to prevent clostridium difficile, or C. diff, infections. The study is enrolling people over age 50 who are at high risk of catching C. diff, but have no prior history of C. diff infection.
Potential Trial Candidates:
- 50+ years of age
- At least two hospital stays of 24 hours+ and receiving antibiotics in the past year
- Anticipating a hospital stay of at least 72 hours within the next 60 days
What is C. diff?
Clostridium difficile, more commonly referred to as C. diff, is a germ that can cause illness ranging in symptoms from mild diarrhea to life-threatening bowel disease. In some cases, it can lead to the removal of the colon and even death. According to the Center for Disease Control, C. diff infections occur in about half a million people each year in the United States. It is the most common cause of infectious healthcare associated diarrhea worldwide.
While C. diff infections occasionally cause problems in individuals with no known risk factors, there are some who are at a greater risk for contracting it. These risk factors include:
- Staying in a health care facility (i.e., hospitals, nursing homes, and long-term care facilities
- Frequent, recent, or long-term use of antibiotics
- Advanced age
- Weakened immune system
There are currently no approved treatments to prevent C. diff infection.
Why is prevention needed?
- Over the last 10 years C. diff infection rates have increased 4-fold.
- Once you have had a C. diff infection you are more at risk of contracted it again. 1 out of 5 people who have a had C. diff infection will become ill with it again at some later time.
- C. diff spores are resistant to most routine cleaning measures and can survive on certain surfaces for months.
- C. diff is easy to transmit and it is difficult to control once present in an environment.
Vaccination to prevent C. diff could be a cost-effective and important public health measure to protect individuals from this devastating disease.
Click here to learn more about C. diff and why it is important to find a treatment to help prevent it.
Click here to view people’s stories on how this disease has impacted their lives.
If you think you may be at risk for C. diff infection and would like to see if you qualify for our C. diff vaccine study, please contact our ARC Clinical Research team at 512-225-5931, or contact us online.